I had a HD crash back a few months ago. which forced me to have to re install all my content. But I had everything I created back up on a another drive. So Spryo if you back up your folders with the content you want to keep you should be alright when you do a clean install. when i did the install i made 3 runtime content folders.
One just for characters and clothing & hair. . One just for environments & VFX tools., and one for everything else i could not categorize.. like trucks ,cars boats and airplanes, buildings Etc..
the lights and camera’ and shader’s create their own folders so i didn’t have make any for those. it really has helped doing it that way to find content easier,