Ah, you didn’t say it was only in DS that it was a problem. There shouldn’t need to be any special settings for using the tablet in DS, and my Intuos 3 is working in 4.5 right now (I think it was working in 4.0, too, though I don’t generally use the tablet in DS). You could check to see if you have, again by action or file corruption, got any odd settings assigned to DS in the Intuos control panel (assuming that’s not what you mean in your last post). If you haven’t made any changes to the Intuos settings yourself you could try running the little utility to reset it to the factory state.