Are you talking about “Perfect V4” from Renderosity? I am using the same product and I have no problems with it.
Here is my workflow for using it:
1. load “Perfect V4”
2. Turn off limits and turn off IK
3. Inject other morphs as needed (Base Morphs, Morphs++ etc.)
4. Apply clothing, hair and all you need.
5. Shape V4
6. Pose V4
7. as a last step inject the “Perfect V4” fixes!
This way I never had any problems. Some pokes with clothes are normal if the clothes do not have the morphs you use on V4, but that is normal. Most of the time a smoothing modifier on that piece of cloth cures the problem.