I'd like to be able to maintain one set of Runtimes, and have them accessible from OS X Lion and Windows 7 x64 over NAS. Is this possible?
I don't use Poser with Vue so I cannot answer that but in theory it should as I have Poser 8 and DS3A and DS4.5 using all the same Content folders including runtimes.
I haven't done it yet but it is possible (at least for DS and Poser...not sure about Vue).
There are others who do have a centralized content server (cough **Kendall**)...and it works well.