The answer to your question is “it depends…”
* Some items with both Poser and DAZ|Studio installers have only D|S materials presets in the D|S installer, which will usually have a much smaller file size than the Poser installer. You will need to run both installers.
* Some items have full Poser and D|S installers, you will only need to run one or the other, and the file sizes should be not too different. (They won’t be the same, because of the different way Poser and D|S do things.)
* Many items released in the last year or so include D|S files in the Poser installer. In this case there might not be a D|S installer.
* Many newer items will only work in D|S 4 or 4.5 — these should have “trx” in the file name, although some have the “trx” when they shouldn’t (work OK in D|S3) or don’t have it when they should (usually texture sets for Genesis stuff, which can’t be used in D|S3 anyway).
It should tell you on the store page if any of these apply, but sometimes the store page info is… less than completely accurate. If this happens, the DAZ 30-day return policy is your friend.